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KMID : 1101720200240010019
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Physical Activity and Nutrition
2020 Volume.24 No. 1 p.19 ~ p.23
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Hypoxic exposure can improve blood glycemic control in high-fat diet-induced obese mice
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Park Ye-Ram
Jang In-Kwon
Park Hun-Young
Kim Ji-Su
Lim Ki-Won
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Abstract
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Purpose: Blood glucose and insulin resistance were lower following hypoxic exposure in previous studies. However, the effect of hypoxia as therapy in obese model has not been unknown.
Methods: Six-week-old mice were randomly divided into chow diet (n=10) and high-fat diet (HFD) groups (n=20). The chow diet group received a non-purified commercial diet (65 % carbohydrate, 21 % protein, and 14 % fat) and water ad libitum. The HFD group was fed an HFD (Research Diet, #D12492; 60% kcal from fat, 5.24 kcal/g). Both groups consumed their respective diet for 7 weeks. Subsequently, HFD-induced mice (12-weeks-old) were randomly divided into two treatment groups : HFD-Normoxia (HFD; n=10) and HFD-Hypoxia (HYP; n=10, fraction of inspired=14.6%). After treatment for 4 weeks, serum glucose, insulin and oral glucose tolerance tests (OGTT) were performed.
Results: Homeostatic model assessment values for insulin resistance (HOMA-IR) of the HYP group tended to be lower than the HFD group. Regarding the OGTT, the area under the curve was 13% lower for the HYP group than the HFD group.
Conclusion: Insulin resistance tended to be lower and glucose uptake capacity was significantly augmented under hypoxia. From a clinical perspective, exposure to hypoxia may be a practical method of treating obesity.
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KEYWORD
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Hypoxia, OGTT, insulin, diabetes, HOMA-IR, blood glucose, obesity
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